Phenotypic characterization of genetically lowered human lipoprotein(a) levels

Phenotypic characterization of genetically lowered human lipoprotein(a) levels

BACKGROUND: Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk factor for coronary heart disease (CHD). As such, lowering Lp(a) levels has emerged as a therapeutic strategy. Beyond target identification, human geneti...

Full description

Bibliographic Details
Main Authors: Emdin, C, Khera, A, Natarajan, P, Klarin, D, Won, H, Peloso, G, Stitziel, N, Nomura, A, Zekavat, S, Bick, A, Gupta, N, Asselta, R, Duga, S, Merlini, P, Correa, A, Kessler, T, Wilson, J, Bown, M, Hall, A, Braund, P, Samani, N, Schunkert, H, Marrugat, J, Elosua, R, McPherson, R, Farrall, M, Watkins, H, Willer, C, Abecasis, G, Felix, J, Vasan, R, Lander, E, Rader, D, Danesh, J, Ardissino, D, Gabriel, S, Saleheen, D, Kathiresan, S, CHARGE–Heart Failure Consortium, CARDIoGRAM Exome Consortium
Format: Journal article
Language:English
Published: Elsevier 2016

Similar Items