POINT technology illuminates the processing of polymerase-associated intact nascent transcripts

Mammalian chromatin is the site of both RNA polymerase II (Pol II) transcription and coupled RNA processing. However, molecular details of such co-transcriptional mechanisms remain obscure, partly because of technical limitations in purifying authentic nascent transcripts. We present a new approach...

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Bibliographic Details
Main Authors: Sousa-Luís, R, Dujardin, G, Zukher, I, Kimura, H, Weldon, C, Carmo-Fonseca, M, Proudfoot, NJ, Nojima, T
Format: Journal article
Language:English
Published: Cell Press 2021