Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.

Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.

Our understanding of the perturbation of normal cellular differentiation hierarchies to create tumor-propagating stem cell populations is incomplete. In human acute myeloid leukemia (AML), current models suggest transformation creates leukemic stem cell (LSC) populations arrested at a progenitor-lik...

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Detalles Bibliográficos
Autores principales: Quek, L, Otto, G, Garnett, C, Lhermitte, L, Karamitros, D, Stoilova, B, Lau, I, Doondeea, J, Usukhbayar, B, Kennedy, A, Metzner, M, Goardon, N, Ivey, A, Allen, C, Gale, R, Davies, B, Sternberg, A, Killick, S, Hunter, H, Cahalin, P, Price, A, Carr, A, Griffiths, M, Virgo, P, Mackinnon, S, Grimwade, D, Freeman, S, Russell, N, Craddock, C, Mead, A, Peniket, A, Porcher, C, Vyas, P
Formato: Journal article
Lenguaje:English
Publicado: Rockefeller University Press 2016

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