Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites.
Both the sequence of a promoter and the position of a gene in 3D nuclear space play crucial roles in gene regulation, but few studies address their inter-relationship. Using human and viral promoters on mini-chromosomes and RNA fluorescence in situ hybridization coupled to 'high-precision'...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2013
|
| _version_ | 1826284799859359744 |
|---|---|
| author | Larkin, J Papantonis, A Cook, P |
| author_facet | Larkin, J Papantonis, A Cook, P |
| author_sort | Larkin, J |
| collection | OXFORD |
| description | Both the sequence of a promoter and the position of a gene in 3D nuclear space play crucial roles in gene regulation, but few studies address their inter-relationship. Using human and viral promoters on mini-chromosomes and RNA fluorescence in situ hybridization coupled to 'high-precision' localization, we show that promoters binding the same transcription factors and responding to the same signaling pathways tend to be co-transcribed in the same transcription factories. We go on to suggest how such spatial co-association might drive co-regulation of genes under the control of similar cis-elements. |
| first_indexed | 2024-03-07T01:19:16Z |
| format | Journal article |
| id | oxford-uuid:8fc9744e-19c8-40d8-ad95-de8f3b60d8fe |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:19:16Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:8fc9744e-19c8-40d8-ad95-de8f3b60d8fe2022-03-26T23:06:45ZPromoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8fc9744e-19c8-40d8-ad95-de8f3b60d8feEnglishSymplectic Elements at Oxford2013Larkin, JPapantonis, ACook, PBoth the sequence of a promoter and the position of a gene in 3D nuclear space play crucial roles in gene regulation, but few studies address their inter-relationship. Using human and viral promoters on mini-chromosomes and RNA fluorescence in situ hybridization coupled to 'high-precision' localization, we show that promoters binding the same transcription factors and responding to the same signaling pathways tend to be co-transcribed in the same transcription factories. We go on to suggest how such spatial co-association might drive co-regulation of genes under the control of similar cis-elements. |
| spellingShingle | Larkin, J Papantonis, A Cook, P Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites. |
| title | Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites. |
| title_full | Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites. |
| title_fullStr | Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites. |
| title_full_unstemmed | Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites. |
| title_short | Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites. |
| title_sort | promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites |
| work_keys_str_mv | AT larkinj promotertypeinfluencestranscriptionaltopographybytargetinggenestodistinctnucleoplasmicsites AT papantonisa promotertypeinfluencestranscriptionaltopographybytargetinggenestodistinctnucleoplasmicsites AT cookp promotertypeinfluencestranscriptionaltopographybytargetinggenestodistinctnucleoplasmicsites |