ARIBA: rapid antimicrobial resistance genotyping directly from sequencing reads

ARIBA: rapid antimicrobial resistance genotyping directly from sequencing reads

Antimicrobial resistance (AMR) is one of the major threats to human and animal health worldwide, yet few high-throughput tools exist to analyse and predict the resistance of a bacterial isolate from sequencing data. Here we present a new tool, ARIBA, that identifies AMR-associated genes and single n...

Descripció completa

Dades bibliogràfiques
Autors principals: Hunt, M, Mather, AE, Sánchez-Busó, L, Page, AJ, Parkhill, J, Keane, JA, Harris, SR
Format: Journal article
Idioma:English
Publicat: Microbiology Society 2017
Descripció
Sumari:Antimicrobial resistance (AMR) is one of the major threats to human and animal health worldwide, yet few high-throughput tools exist to analyse and predict the resistance of a bacterial isolate from sequencing data. Here we present a new tool, ARIBA, that identifies AMR-associated genes and single nucleotide polymorphisms directly from short reads, and generates detailed and customizable output. The accuracy and advantages of ARIBA over other tools are demonstrated on three datasets from Gram-positive and Gram-negative bacteria, with ARIBA outperforming existing methods.

Ítems similars