Chiral epoxides by desymmetrizing deprotonation of meso-epoxides.
Simple meso-epoxides can be asymmetrically functionalized: Ligand-assisted direct hydrogen-lithium exchange allows the generation of destabilized oxiranyl lithium species and their subsequent trapping by a wide array of electrophiles (see scheme; E = group formed by addition of electrophile). When c...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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