Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

Chronic infections strain the regenerative capacity of antiviral T lymphocyte populations, leading to failure in long-term immunity. The cellular and molecular events controlling this regenerative capacity, however, are unknown. We found that two distinct states of virus-specific CD8(+) T cells exis...

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Bibliographic Details
Main Authors: Paley, M, Kroy, D, Odorizzi, P, Johnnidis, J, Dolfi, D, Barnett, B, Bikoff, E, Robertson, E, Lauer, G, Reiner, S, Wherry, E
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2012