Parallel reverse genetic screening in mutant human cells using transcriptomics

Reverse genetic screens have driven gene annotation and target discovery in model organisms. However, many disease‐relevant genotypes and phenotypes cannot be studied in lower organisms. It is therefore essential to overcome technical hurdles associated with large‐scale reverse genetics in human cel...

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Detalhes bibliográficos
Principais autores: Gapp, B, Konopka, T, Penz, T, Dalal, V, Bürckstümmer, T, Bock, C, Nijman, S
Formato: Journal article
Publicado em: EMBO Press 2016