Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the 2 KDEL receptor

Selective export and retrieval of proteins between the endoplasmic reticulum (ER) and Golgi apparatus is indispensable for eukaryotic cell function. An essential step in the retrieval of ER luminal proteins from the Golgi is the pH-dependent recognition of a carboxyl-terminal Lys-Asp-Glu-Leu (KDEL)...

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Détails bibliographiques
Auteurs principaux: Brauer, P, Parker, J, Gerondopoulos, A, Zimmermann, I, Seeger, M, Barr, F, Newstead, S
Format: Journal article
Publié: American Association for the Advancement of Science 2019