Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients

Maintenance of bacterial cell shape and resistance to osmotic stress by the peptidoglycan (PG) renders PG biosynthetic enzymes and precursors attractive targets for combating bacterial infections. Here, by applying native mass spectrometry, we elucidate the effects of lipid substrates on the PG memb...

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Bibliographic Details
Main Authors: Oluwole, AO, Corey, RA, Brown, CM, Hernández-Rocamora, VM, Stansfeld, PJ, Vollmer, W, Bolla, JR, Robinson, CV
Format: Journal article
Language:English
Published: Springer Nature 2022