Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26

Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26

N‐Methylation of lysyl residues is widely observed on histone proteins. Using isolated enzymes, we report mechanistic and structural studies on histone lysine demethylase (KDM)‐catalysed demethylation of Nε‐methylated lysine 26 on histone 1 isotype 4 (H1.4). The results reveal that methylated H1.4K2...

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Xehetasun bibliografikoak
Egile Nagusiak:	Walport, L, Hopkinson, R, Chowdhury, R, Zhang, Y, Bonnici, J, Schiller, R, Kawamura, A, Schofield, C
Formatua:	Journal article
Argitaratua:	Wiley 2018

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nork: Langley, G, et al.
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nork: Suzuki, T, et al.
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nork: Thinnes, C, et al.
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nork: Belle, R, et al.
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Mechanisms of human histone and nucleic acid demethylases
nork: Walport, L, et al.
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Mechanisms of human histone and nucleic acid demethylases.
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nork: Hancock, R, et al.
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nork: Hancock, R
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nork: Klose, R, et al.
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Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry.
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Histone Lysine Demethylases KDM5B and KDM5C Modulate Genome Activation and Stability in Porcine Embryos
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Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
nork: Walport, L, et al.
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nork: Dunne, K
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Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
nork: Qing-Jun Zhang, et al.
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Regulation of histone methylation by demethylimination and demethylation.
nork: Klose, R, et al.
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Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation.
nork: Cheng Liu, et al.
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The role of the lysine demethylases KDM5 and KDM6 in bone malignancies
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Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications
nork: Hsu, K-F, et al.
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