Designing logical codon reassignment - Expanding the chemistry in biology

Over the last decade, the ability to genetically encode unnatural amino acids (UAAs) has evolved rapidly. The programmed incorporation of UAAs into recombinant proteins relies on the reassignment or suppression of canonical codons with an amino-acyl tRNA synthetase/tRNA (aaRS/tRNA) pair, selective f...

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Bibliographic Details
Main Authors: Dumas, A, Lercher, L, Spicer, C, Davis, B
Format: Journal article
Published: Royal Society of Chemistry 2015