Functional and informatics analysis enables glycosyltransferase activity prediction

The elucidation and prediction of how changes in a protein result in altered activities and selectivities remain a major challenge in chemistry. Two hurdles have prevented accurate family-wide models: obtaining (i) diverse datasets and (ii) suitable parameter frameworks that encapsulate activities i...

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Bibliographic Details
Main Authors: Yang, M, Fehl, C, Lees, KV, Lim, E-K, Offen, WA, Davies, GJ, Bowles, DJ, Davidson, MG, Roberts, SJ, Davis, BG
Format: Journal article
Language:English
Published: Nature Publishing Group 2018