Structure-guided design of an IL-1β immunogen for the treatment of autoinflammatory diseases
Systemic autoinflammatory diseases are a group of immunological disorders char-acterised by recurrent events of generalised sterile inflammation. Central to the patho-genesis of most SAIDs is the overproduction of interleukin-1β, a potent proinflamma-tory cytokine normally secreted by cells of the i...
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| Format: | Thesis |
| Language: | English |
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2024
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