GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

Glucagon secretion is inhibited by glucagon-like peptide-1 (GLP-1) and stimulated by adrenaline. These opposing effects on glucagon secretion are mimicked by low (1-10 nM) and high (10 muM) concentrations of forskolin, respectively. The expression of GLP-1 receptors in alpha cells is <0.2% of...

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Bibliographic Details
Main Authors:	De Marinis, Y, Salehi, A, Ward, C, Zhang, Q, Abdulkader, F, Bengtsson, M, Braha, O, Braun, M, Ramracheya, R, Amisten, S, Habib, A, Moritoh, Y, Zhang, E, Reimann, F, Rosengren, A, Shibasaki, T, Gribble, F, Renström, E, Seino, S, Eliasson, L, Rorsman, P
Format:	Journal article
Language:	English
Published:	2010

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

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