Expression of opsin genes early in ocular development of humans and mice.

We have compared the onsets of expression of the classical visual opsins with those of the non-rod, non-cone opsins in foetal and post-natal eye tissue from mice and humans. Mouse Rgr-opsin, peropsin, encephalopsin and melanopsin are all expressed in foetal development by E11.5, unlike the murine ro...

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Detaylı Bibliyografya
Asıl Yazarlar: Tarttelin, E, Bellingham, J, Bibb, L, Foster, R, Hankins, M, Gregory-Evans, K, Gregory-Evans, C, Wells, D, Lucas, R
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 2003
Diğer Bilgiler
Özet:We have compared the onsets of expression of the classical visual opsins with those of the non-rod, non-cone opsins in foetal and post-natal eye tissue from mice and humans. Mouse Rgr-opsin, peropsin, encephalopsin and melanopsin are all expressed in foetal development by E11.5, unlike the murine rod and cone opsins that exhibit post-natal expression, e.g. P1 for ultraviolet cone opsin and P5 for rod opsin. Human non-rod, non-cone opsins are also all expressed early, by 8.6 weeks post-conception. The implications of these observations are discussed with regard to the possible functions of these opsins at early stages of ocular development.