Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.

Abnormalities of chromosome 7q are common in myeloid malignancies, but no specific target genes have yet been identified. Here, we describe the finding of homozygous EZH2 mutations in 9 of 12 individuals with 7q acquired uniparental disomy. Screening of a total of 614 individuals with myeloid disord...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Ernst, T, Chase, A, Score, J, Hidalgo-Curtis, C, Bryant, C, Jones, A, Waghorn, K, Zoi, K, Ross, F, Reiter, A, Hochhaus, A, Drexler, H, Duncombe, A, Cervantes, F, Oscier, D, Boultwood, J, Grand, F, Cross, N
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2010

Eitemau Tebyg

Inactivating mutations of the histone methyltransferase EZH2 in myeloid disorders
gan: Ernst, T, et al.
Cyhoeddwyd: (2010)

INACTIVATING MUTATIONS OF THE HISTONE METHYLTRANSFERASE EZH2 ARE ASSOCIATED WITH CHROMOSOME 7 ABNORMALITIES IN MYELOID DISORDERS
gan: Ernst, T, et al.
Cyhoeddwyd: (2010)

Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms
gan: Thomas Ernst, et al.
Cyhoeddwyd: (2010-09-01)

EZH2 in Myeloid Malignancies
gan: Jenny Rinke, et al.
Cyhoeddwyd: (2020-07-01)

Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
gan: Su, I-hsin, et al.
Cyhoeddwyd: (2013)

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.
gan: Pereira, J, et al.
Cyhoeddwyd: (2010)

Histone Methyltransferase EZH2: A Potential Therapeutic Target for Kidney Diseases
gan: Tingting Li, et al.
Cyhoeddwyd: (2021-02-01)

The Role of the Histone Methyltransferase EZH2 in Liver Inflammation and Fibrosis in STAM NASH Mice
gan: Seul Lee, et al.
Cyhoeddwyd: (2020-05-01)

Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML
gan: Julia M. Kempf, et al.
Cyhoeddwyd: (2021-03-01)

Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastoma
gan: Janith A. Seneviratne, et al.
Cyhoeddwyd: (2024-11-01)

Essential roles of histone lysine methyltransferases EZH2 and EHMT1 in male embryo development of Phenacoccus solenopsis
gan: Haojie Tong, et al.
Cyhoeddwyd: (2024-08-01)

m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2
gan: Junchen Chen, et al.
Cyhoeddwyd: (2019-04-01)

Dysregulated recruitment of the histone methyltransferase EZH2 to the class II transactivator (CIITA) promoter IV in breast cancer cells.
gan: Agnieszka D Truax, et al.
Cyhoeddwyd: (2012-01-01)

EZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy
gan: Sopita Visamol, et al.
Cyhoeddwyd: (2024-04-01)

EZH2 mediated metabolic rewiring promotes tumor growth independently of histone methyltransferase activity in ovarian cancer
gan: Jianfeng Chen, et al.
Cyhoeddwyd: (2023-05-01)

The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation
gan: Machiko Kojima, et al.
Cyhoeddwyd: (2019-05-01)

Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells
gan: Y. Sbirkov, et al.
Cyhoeddwyd: (2023-03-01)

A histone methyltransferase modulates antigenic variation in African trypanosomes.
gan: Luisa M Figueiredo, et al.
Cyhoeddwyd: (2008-07-01)

EZH2 Methyltransferase Regulates Neuroinflammation and Neuropathic Pain
gan: Han-Rong Weng, et al.
Cyhoeddwyd: (2023-03-01)

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia
gan: Parker, H, et al.
Cyhoeddwyd: (2016)

Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis
gan: Christopher T Rhodes, et al.
Cyhoeddwyd: (2023-01-01)

3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells.
gan: Nicolas Girard, et al.
Cyhoeddwyd: (2014-01-01)

Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens
gan: Jesse H. Arbuckle, et al.
Cyhoeddwyd: (2017-09-01)

The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis
gan: Bibhu P. Mishra, et al.
Cyhoeddwyd: (2014-05-01)

On the histone lysine methyltransferase activity of fungal metabolite chaetocin.
gan: Cherblanc, F, et al.
Cyhoeddwyd: (2013)

MiR-26a Mediates Ultraviolet B-Induced Apoptosis by Targeting Histone Methyltransferase EZH2 Depending on Myc Expression
gan: Ting Zhang, et al.
Cyhoeddwyd: (2017-10-01)

Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism.
gan: Adriana S A Pereira, et al.
Cyhoeddwyd: (2018-10-01)

Histone Methyltransferase Assay in vitro
gan: Pengfei Sui, et al.
Cyhoeddwyd: (2012-12-01)

EZH2 promotes proliferation and invasiveness of prostate cancer cells.
gan: Bryant, R, et al.
Cyhoeddwyd: (2007)

Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells
gan: Takaya Ichikawa, et al.
Cyhoeddwyd: (2018-12-01)

Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases.
gan: Rajnee Kanwal, et al.
Cyhoeddwyd: (2016-01-01)

Overactivation of histone deacetylases and EZH2 in Wilms tumorigenesis
gan: Chao-Hui Chen, et al.
Cyhoeddwyd: (2023-09-01)

A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon α
gan: Sebastian Kreil, et al.
Cyhoeddwyd: (2010-01-01)

Targets of histone H3 lysine 9 methyltransferases
gan: Aidan J. Levinsky, et al.
Cyhoeddwyd: (2022-12-01)

The Polycomb Group protein EZH2 regulates actin polymerization in human prostate cancer cells.
gan: Bryant, R, et al.
Cyhoeddwyd: (2008)

Histone methyltransferase and drug resistance in cancers
gan: Cheng Yang, et al.
Cyhoeddwyd: (2020-08-01)

Correction: Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases.
gan: Rajnee Kanwal, et al.
Cyhoeddwyd: (2016-01-01)

Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas
gan: Makoto Yamagishi, et al.
Cyhoeddwyd: (2019-11-01)

DZNep, an inhibitor of the histone methyltransferase EZH2, suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 pathway
gan: Rongrong Ding, et al.
Cyhoeddwyd: (2021-05-01)

The Roles of the Histone Protein Modifier EZH2 in the Uterus and Placenta
gan: Ana M. Mesa, et al.
Cyhoeddwyd: (2020-09-01)