Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.

Abnormalities of chromosome 7q are common in myeloid malignancies, but no specific target genes have yet been identified. Here, we describe the finding of homozygous EZH2 mutations in 9 of 12 individuals with 7q acquired uniparental disomy. Screening of a total of 614 individuals with myeloid disord...

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Detalhes bibliográficos
Principais autores:	Ernst, T, Chase, A, Score, J, Hidalgo-Curtis, C, Bryant, C, Jones, A, Waghorn, K, Zoi, K, Ross, F, Reiter, A, Hochhaus, A, Drexler, H, Duncombe, A, Cervantes, F, Oscier, D, Boultwood, J, Grand, F, Cross, N
Formato:	Journal article
Idioma:	English
Publicado em:	2010

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