Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

Non-viral aerosol gene therapy offers great potential for treating chronic lung diseases of the airways such as cystic fibrosis (CF). Early clinical trials showed that transgene expression in the airways was transient whereas maximal duration of transgene expression is essential in order to minimise...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Bazzani, R, Pringle, I, Connolly, M, Davies, L, Sumner-Jones, S, Schleef, M, Hyde, S, Gill, D
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Elsevier 2016

Παρόμοια τεκμήρια

743. Minicircles are similar to plasmids in providing high level, long-term expression in the lung
ανά: Gill, D, κ.ά.
Έκδοση: (2016)

Influence of CpG-dinucleotide motifs on the duration of gene expression from plasmid, vectors after in vivo lung delivery
ανά: Gill, DR, κ.ά.
Έκδοση: (2007)

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy
ανά: Pringle, I, κ.ά.
Έκδοση: (2012)

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy.
ανά: Pringle, I, κ.ά.
Έκδοση: (2012)

DEVELOPMENT, PRODUCTION AND EVALUATION OF CLINICAL GRADE CFTR EXPRESSION PLASMID FOR CF LUNG GENE THERAPY
ανά: Gill, DR, κ.ά.
Έκδοση: (2010)

An Alternative Class of Targets for microRNAs Containing CG Dinucleotide
ανά: Wennan Dai, κ.ά.
Έκδοση: (2022-03-01)

The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes.
ανά: Davies, L, κ.ά.
Έκδοση: (2012)

Strategies for long-term expression of transgenes in the respiratory epithelium.
ανά: Gill, DR, κ.ά.
Έκδοση: (2010)

Progress and prospects: the design and production of plasmid vectors.
ανά: Gill, DR, κ.ά.
Έκδοση: (2009)

Tracking myeloid malignancies by targeted analysis of successive DNA methylation at neighboring CG dinucleotides
ανά: Monika Eipel, κ.ά.
Έκδοση: (2019-08-01)

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
ανά: Hyde, S, κ.ά.
Έκδοση: (2008)

Plasmids for therapy and vaccination /
ανά: Schleef, M. (Martin)
Έκδοση: (2001)

Plasmid Inhalation: Delivery to the Airways
ανά: Davies, L, κ.ά.
Έκδοση: (2006)

HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP
ανά: Paola Miyazato, κ.ά.
Έκδοση: (2019-12-01)

Elimination of the plasmid bacterial backbone in site-directed transgenesis
ανά: Jannik E. Jakobsen, κ.ά.
Έκδοση: (2010-04-01)

The significance of plasmid DNA preparations contaminated with bacterial genomic DNA on inflammatory responses following delivery of lipoplexes to the murine lung.
ανά: Bazzani, R, κ.ά.
Έκδοση: (2011)

Detection of plasmid DNA vectors following gene transfer to the murine airways.
ανά: Pringle, I, κ.ά.
Έκδοση: (2005)

Generation of marker- and/or backbone-free transgenic wheat plants via Agrobacterium-mediated transformation
ανά: Wang Genping, κ.ά.
Έκδοση: (2016-09-01)

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.
ανά: Pringle, I, κ.ά.
Έκδοση: (2007)

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
ανά: Hyde, Stephen C., κ.ά.
Έκδοση: (2008)

Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio
ανά: Zengzeng Lu, κ.ά.
Έκδοση: (2022-12-01)

AdEasy System Made Easier by Selecting the Viral Backbone Plasmid Preceding Homologous Recombination
ανά: M. Zeng, κ.ά.
Έκδοση: (2001-08-01)

Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.
ανά: Davies, L, κ.ά.
Έκδοση: (2005)

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.
ανά: Gill, DR, κ.ά.
Έκδοση: (2001)

Synonymous Dinucleotide Usage: A Codon-Aware Metric for Quantifying Dinucleotide Representation in Viruses
ανά: Spyros Lytras, κ.ά.
Έκδοση: (2020-04-01)

Truncating the C terminus of formate dehydrogenase leads to improved preference to nicotinamide cytosine dinucleotide
ανά: Xiaojia Guo, κ.ά.
Έκδοση: (2024-11-01)

RECONsidering sensing of cyclic dinucleotides
ανά: Maelfait, J, κ.ά.
Έκδοση: (2017)

Synthesis of Mixed Dinucleotides by Mechanochemistry
ανά: Faisal Hayat, κ.ά.
Έκδοση: (2022-05-01)

Repertoires of the nucleosome-positioning dinucleotides.
ανά: Thomas Bettecken, κ.ά.
Έκδοση: (2009-01-01)

Lack of repeat transduction by recombinant adeno-associated virus type 5/5 vectors in the mouse airway.
ανά: Sumner-Jones, S, κ.ά.
Έκδοση: (2007)

Rational Development of A Polycistronic Plasmid with A CpG-Free Bacterial Backbone as A Potential Tool for Direct Reprogramming
ανά: Kianoush Dormiani, κ.ά.
Έκδοση: (2016-10-01)

Long-term persistence of gene expression from adeno-associated virus serotype 5 in the mouse airways.
ανά: Sumner-Jones, S, κ.ά.
Έκδοση: (2006)

Backbone-independent NMR resonance assignments of methyl probes in large proteins
ανά: Santrupti Nerli, κ.ά.
Έκδοση: (2021-01-01)

An investigation into persistent transgene expression from plasmid vectors in the lung
ανά: Oliveira, C
Έκδοση: (2016)

Backbone
ανά: Brandon Wint
Έκδοση: (2022-10-01)

backbone: An R package to extract network backbones
ανά: Zachary P. Neal
Έκδοση: (2022-01-01)

backbone: An R package to extract network backbones.
ανά: Zachary P Neal
Έκδοση: (2022-01-01)

Genome Analysis of Nicotinamide Adenine Dinucleotide-Independent <i>Mycoplasma synoviae</i> Isolates From Korea
ανά: Yongjun Song, κ.ά.
Έκδοση: (2021-09-01)

Polymer Backbone Stabilized Methylammonium Lead Bromide Perovskite Nano Islands
ανά: Chinna Bathula, κ.ά.
Έκδοση: (2023-10-01)

The development of gene therapy for diseases of the lung.
ανά: Gill, DR, κ.ά.
Έκδοση: (2004)