Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

Non-viral aerosol gene therapy offers great potential for treating chronic lung diseases of the airways such as cystic fibrosis (CF). Early clinical trials showed that transgene expression in the airways was transient whereas maximal duration of transgene expression is essential in order to minimise...

書誌詳細
主要な著者:	Bazzani, R, Pringle, I, Connolly, M, Davies, L, Sumner-Jones, S, Schleef, M, Hyde, S, Gill, D
フォーマット:	Journal article
言語:	English
出版事項:	Elsevier 2016

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