Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

Non-viral aerosol gene therapy offers great potential for treating chronic lung diseases of the airways such as cystic fibrosis (CF). Early clinical trials showed that transgene expression in the airways was transient whereas maximal duration of transgene expression is essential in order to minimise...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Bazzani, R, Pringle, I, Connolly, M, Davies, L, Sumner-Jones, S, Schleef, M, Hyde, S, Gill, D
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	Elsevier 2016

Gelijkaardige items

743. Minicircles are similar to plasmids in providing high level, long-term expression in the lung
door: Gill, D, et al.
Gepubliceerd in: (2016)

Influence of CpG-dinucleotide motifs on the duration of gene expression from plasmid, vectors after in vivo lung delivery
door: Gill, DR, et al.
Gepubliceerd in: (2007)

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy
door: Pringle, I, et al.
Gepubliceerd in: (2012)

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy.
door: Pringle, I, et al.
Gepubliceerd in: (2012)

DEVELOPMENT, PRODUCTION AND EVALUATION OF CLINICAL GRADE CFTR EXPRESSION PLASMID FOR CF LUNG GENE THERAPY
door: Gill, DR, et al.
Gepubliceerd in: (2010)

The tendency to recreate ancestral CG dinucleotides in the human genome
door: Li Mingkun, et al.
Gepubliceerd in: (2011-01-01)

The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes.
door: Davies, L, et al.
Gepubliceerd in: (2012)

An Alternative Class of Targets for microRNAs Containing CG Dinucleotide
door: Wennan Dai, et al.
Gepubliceerd in: (2022-03-01)

Strategies for long-term expression of transgenes in the respiratory epithelium.
door: Gill, DR, et al.
Gepubliceerd in: (2010)

Progress and prospects: the design and production of plasmid vectors.
door: Gill, DR, et al.
Gepubliceerd in: (2009)

Tracking myeloid malignancies by targeted analysis of successive DNA methylation at neighboring CG dinucleotides
door: Monika Eipel, et al.
Gepubliceerd in: (2019-08-01)

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
door: Hyde, S, et al.
Gepubliceerd in: (2008)

Plasmid Inhalation: Delivery to the Airways
door: Davies, L, et al.
Gepubliceerd in: (2006)

Plasmids for therapy and vaccination /
door: Schleef, M. (Martin)
Gepubliceerd in: (2001)

HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP
door: Paola Miyazato, et al.
Gepubliceerd in: (2019-12-01)

Elimination of the plasmid bacterial backbone in site-directed transgenesis
door: Jannik E. Jakobsen, et al.
Gepubliceerd in: (2010-04-01)

The significance of plasmid DNA preparations contaminated with bacterial genomic DNA on inflammatory responses following delivery of lipoplexes to the murine lung.
door: Bazzani, R, et al.
Gepubliceerd in: (2011)

Detection of plasmid DNA vectors following gene transfer to the murine airways.
door: Pringle, I, et al.
Gepubliceerd in: (2005)

Generation of marker- and/or backbone-free transgenic wheat plants via Agrobacterium-mediated transformation
door: Wang Genping, et al.
Gepubliceerd in: (2016-09-01)

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.
door: Pringle, I, et al.
Gepubliceerd in: (2007)

Author Correction: Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames
door: Yong Wang, et al.
Gepubliceerd in: (2021-06-01)

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
door: Hyde, Stephen C., et al.
Gepubliceerd in: (2008)

Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio
door: Zengzeng Lu, et al.
Gepubliceerd in: (2022-12-01)

AdEasy System Made Easier by Selecting the Viral Backbone Plasmid Preceding Homologous Recombination
door: M. Zeng, et al.
Gepubliceerd in: (2001-08-01)

Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.
door: Davies, L, et al.
Gepubliceerd in: (2005)

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.
door: Gill, DR, et al.
Gepubliceerd in: (2001)

Synonymous Dinucleotide Usage: A Codon-Aware Metric for Quantifying Dinucleotide Representation in Viruses
door: Spyros Lytras, et al.
Gepubliceerd in: (2020-04-01)

Truncating the C terminus of formate dehydrogenase leads to improved preference to nicotinamide cytosine dinucleotide
door: Xiaojia Guo, et al.
Gepubliceerd in: (2024-11-01)

RECONsidering sensing of cyclic dinucleotides
door: Maelfait, J, et al.
Gepubliceerd in: (2017)

Synthesis of Mixed Dinucleotides by Mechanochemistry
door: Faisal Hayat, et al.
Gepubliceerd in: (2022-05-01)

Repertoires of the nucleosome-positioning dinucleotides.
door: Thomas Bettecken, et al.
Gepubliceerd in: (2009-01-01)

Lack of repeat transduction by recombinant adeno-associated virus type 5/5 vectors in the mouse airway.
door: Sumner-Jones, S, et al.
Gepubliceerd in: (2007)

Rational Development of A Polycistronic Plasmid with A CpG-Free Bacterial Backbone as A Potential Tool for Direct Reprogramming
door: Kianoush Dormiani, et al.
Gepubliceerd in: (2016-10-01)

Long-term persistence of gene expression from adeno-associated virus serotype 5 in the mouse airways.
door: Sumner-Jones, S, et al.
Gepubliceerd in: (2006)

Backbone-independent NMR resonance assignments of methyl probes in large proteins
door: Santrupti Nerli, et al.
Gepubliceerd in: (2021-01-01)

Backbone
door: Brandon Wint
Gepubliceerd in: (2022-10-01)

backbone: An R package to extract network backbones
door: Zachary P. Neal
Gepubliceerd in: (2022-01-01)

backbone: An R package to extract network backbones.
door: Zachary P Neal
Gepubliceerd in: (2022-01-01)

An investigation into persistent transgene expression from plasmid vectors in the lung
door: Oliveira, C
Gepubliceerd in: (2016)

The development of gene therapy for diseases of the lung.
door: Gill, DR, et al.
Gepubliceerd in: (2004)