Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution
Bisulfite sequencing has been the gold standard for mapping DNA modifications including 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) for decades1,2,3,4. However, this harsh chemical treatment degrades the majority of the DNA and generates sequencing libraries with low complexity2,5,6. H...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Springer Nature
2019
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