Normoxic stabilization of hypoxia-inducible factor-1α by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1
Hypoxia-inducible factor (HIF) is a transcription factor with major roles in many cellular and systemic responses to hypoxia. Activation of HIF pathways under hypoxia is mediated by suppression of the Fe²⁺ - and O₂-dependent HIF hydroxylase enzymes that normally inactive HIFα subunits. Mechanisms un...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Association for Cancer Research
2006
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| Subjects: |