Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals.

BACKGROUND: Circumsporozoite protein (CS) is the antigenic target for RTS,S, the most advanced malaria vaccine to date. Heterologous prime-boost with the viral vectors simian adenovirus 63 (ChAd63)-modified vaccinia virus Ankara (MVA) is the most potent inducer of T-cells in humans, demonstrating s...

Full description

Bibliographic Details
Main Authors:	Hodgson, S, Ewer, K, Bliss, C, Edwards, N, Rampling, T, Anagnostou, N, de Barra, E, Havelock, T, Bowyer, G, Poulton, I, de Cassan, S, Longley, R, Illingworth, J, Douglas, A, Mange, P, Collins, K, Roberts, R, Gerry, S, Berrie, E, Moyle, S, Colloca, S, Cortese, R, Sinden, R, Gilbert, S, Bejon, P, Lawrie, A, Nicosia, A, Faust, SN, Hill, A
Format:	Journal article
Language:	English
Published:	2014

Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals.

Similar Items