MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.
The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic stem cells. Here, we present quantitative, genome-wide analysis of 5hmC, 5-methylcytosine (5mC), and gene expression in differ...
Asıl Yazarlar: | Mellén, M, Ayata, P, Dewell, S, Kriaucionis, S, Heintz, N |
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Materyal Türü: | Journal article |
Dil: | English |
Baskı/Yayın Bilgisi: |
2012
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