The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.

Spinal muscular atrophy (SMA), which is caused by inactivating mutations in the survival motor neuron 1 (SMN1) gene, is characterized by loss of lower motor neurons in the spinal cord. The gene encoding SMN is very highly conserved in evolution, allowing the disease to be modeled in a range of speci...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Sleigh, J, Gillingwater, T, Talbot, K
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2011

Eitemau Tebyg

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