The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.

Spinal muscular atrophy (SMA), which is caused by inactivating mutations in the survival motor neuron 1 (SMN1) gene, is characterized by loss of lower motor neurons in the spinal cord. The gene encoding SMN is very highly conserved in evolution, allowing the disease to be modeled in a range of speci...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Sleigh, J, Gillingwater, T, Talbot, K
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2011

समान संसाधन

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy
द्वारा: James N. Sleigh, और अन्य
प्रकाशित: (2011-07-01)

Spinal muscular atrophy at the crossroads of basic science and therapy
द्वारा: Sleigh, J, और अन्य
प्रकाशित: (2013)

Spinal muscular atrophy at the crossroads of basic science and therapy.
द्वारा: Sleigh, J, और अन्य
प्रकाशित: (2013)

Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy.
द्वारा: Murray, L, और अन्य
प्रकाशित: (2010)

SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy.
द्वारा: Wishart, T, और अन्य
प्रकाशित: (2010)

Spinal muscular atrophy.
द्वारा: Talbot, K, और अन्य
प्रकाशित: (2001)

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.
द्वारा: Bäumer, D, और अन्य
प्रकाशित: (2009)

Development and Translation of Therapies for Spinal Muscular Atrophy
द्वारा: Hannah K. Shorrock, और अन्य
प्रकाशित: (2016-07-01)

Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy.
द्वारा: Murray, L, और अन्य
प्रकाशित: (2008)

Review: neuromuscular synaptic vulnerability in motor neurone disease: amyotrophic lateral sclerosis and spinal muscular atrophy.
द्वारा: Murray, L, और अन्य
प्रकाशित: (2010)

Therapeutic strategies for spinal muscular atrophy: SMN and beyond
द्वारा: Bowerman, M, और अन्य
प्रकाशित: (2017)

Therapeutic strategies for spinal muscular atrophy: SMN and beyond
द्वारा: Bowerman, M, और अन्य
प्रकाशित: (2017)

Chapter 16 Spinal Muscular Atrophy
द्वारा: Talbot, K, और अन्य
प्रकाशित: (2003)

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.
द्वारा: Dirk Bäumer, और अन्य
प्रकाशित: (2009-12-01)

Reversible molecular pathology of skeletal muscle in spinal muscular atrophy.
द्वारा: Mutsaers, C, और अन्य
प्रकाशित: (2011)

Therapeutic strategies for spinal muscular atrophy: SMN and beyond
द्वारा: Melissa Bowerman, और अन्य
प्रकाशित: (2017-08-01)

Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics.
द्वारा: Grice, S, और अन्य
प्रकाशित: (2011)

Invertebrate models of spinal muscular atrophy: Insights into mechanisms and potential therapeutics
द्वारा: Grice, S, और अन्य
प्रकाशित: (2011)

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy
द्वारा: Turner, B, और अन्य
प्रकाशित: (2008)

Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.
द्वारा: Sleigh, J, और अन्य
प्रकाशित: (2014)

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy
द्वारा: Ansorge Olaf, और अन्य
प्रकाशित: (2008-10-01)

Model systems for exploring new therapeutic interventions and disease mechanisms in spinal muscular atrophies (SMAs)
द्वारा: Sleigh, JN
प्रकाशित: (2012)

Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy.
द्वारा: Penelope J Boyd, और अन्य
प्रकाशित: (2017-04-01)

Molecular Pathogenesis and New Therapeutic Dimensions for Spinal Muscular Atrophy
द्वारा: Andrés López-Cortés, और अन्य
प्रकाशित: (2022-06-01)

Chapter 7 Spinal muscular atrophies and hereditary motor neuropathies.
द्वारा: Talbot, K, और अन्य
प्रकाशित: (2007)

Spinal Muscular Atrophy
द्वारा: J Gordon Millichap
प्रकाशित: (1990-02-01)

Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy.
द्वारा: Karen K Y Ling, और अन्य
प्रकाशित: (2010-11-01)

Spinal muscular atrophy
द्वारा: D'Amico Adele, और अन्य
प्रकाशित: (2011-11-01)

The altered expression of neurofilament in mouse models and patients with spinal muscular atrophy
द्वारा: Charlotte Spicer, और अन्य
प्रकाशित: (2021-04-01)

Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy.
द्वारा: Sophie R Thomson, और अन्य
प्रकाशित: (2012-01-01)

Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy
द्वारा: Hammond, S, और अन्य
प्रकाशित: (2016)

Modeling spinal muscular atrophy in Drosophila.
द्वारा: Chang, H, और अन्य
प्रकाशित: (2008)

Modeling spinal muscular atrophy in Drosophila.
द्वारा: Howard Chia-Hao Chang, और अन्य
प्रकाशित: (2008-09-01)

Spinal Muscular Atrophy and Arthrogryposis
द्वारा: J Gordon Millichap
प्रकाशित: (1997-10-01)

Spinal muscular atrophies reveal motor neuron vulnerability to defects in ribonucleoprotein handling.
द्वारा: Anderson, K, और अन्य
प्रकाशित: (2003)

MOLECULAR ANALYSIS OF CHILDHOOD-ONSET SPINAL MUSCULAR-ATROPHY
द्वारा: Theodosiou, A, और अन्य
प्रकाशित: (1995)

Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy
द्वारा: Christian M. Simon, और अन्य
प्रकाशित: (2019-12-01)

Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis
द्वारा: Andrew P. Tosolini, और अन्य
प्रकाशित: (2017-12-01)

R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy
द्वारा: Rocio Tejero, और अन्य
प्रकाशित: (2020-02-01)

Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy
द्वारा: Jamie A. Johansen, और अन्य
प्रकाशित: (2009-04-01)