The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.
Spinal muscular atrophy (SMA), which is caused by inactivating mutations in the survival motor neuron 1 (SMN1) gene, is characterized by loss of lower motor neurons in the spinal cord. The gene encoding SMN is very highly conserved in evolution, allowing the disease to be modeled in a range of speci...
Asıl Yazarlar: | Sleigh, J, Gillingwater, T, Talbot, K |
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Materyal Türü: | Journal article |
Dil: | English |
Baskı/Yayın Bilgisi: |
2011
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