Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes.
<p><strong>OBJECTIVE</strong> Two novel mutations (E1506D, E1506G) in the nucleotide-binding domain 2 (NBD2) of the ATP-sensitive K<sup>+</sup> channel (K<sub>ATP</sub> channel) sulfonylurea receptor 1 (SUR1) subunit were detected heterozygously in patients...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Diabetes Association
2011
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| Subjects: |