New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases.
E3 ubiquitin ligases that direct substrate proteins to the ubiquitin-proteasome system are promising, though largely unexplored drug targets both because of their function and their remarkable specificity. CRLs [Cullin-RING (really interesting new gene) ligases] are the largest group of E3 ligases a...
Main Authors: | , |
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Format: | Journal article |
Language: | English |
Published: |
2014
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