Alpelisib plus fulvestrant in PIK3CA-Altered and PIK3CA-wild-type estrogen receptor–positive advanced breast cancer: A phase 1b clinical trial

<p><strong>Importance</strong> The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in patients with estrogen receptor–positive (ER+), endocrine therapy–resistant breast cancers.</p> <p><strong>Objective</strong> To assess the maximum t...

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Bibliographic Details
Main Authors: Juric, D, Janku, F, Rodón, J, Burris, H, Mayer, I, Schuler, M, Seggewiss-Bernhardt, R, Gil-Martin, M, Middleton, M, Baselga, J, Bootle, D, Demanse, D, Blumenstein, L, Schumacher, K, Huang, A, Quadt, C, Rugo, H
Format: Journal article
Published: American Medical Association 2018