Investigation of the OS-9/Grp94 interaction and its role in Endoplasmic Reticulum-Associated Degradation (ERAD)

<p>Proteins that misfold or are improperly assembled in the endoplasmic reticulum (ER) are exported to the cytosol to be degraded via the ubiquitin-proteasome pathway in a process termed ER-associated degradation (ERAD). The ER resident lectin OS-9 occupies a central role, linking recognition...