The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.
Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and is thus a good candidate gene. Here we report the presence of SHIP2 gene mutations associated wi...
| मुख्य लेखकों: | , , , , , , , , , , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2002
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| _version_ | 1826285413520637952 |
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| author | Marion, E Kaisaki, P Pouillon, V Gueydan, C Levy, J Bodson, A Krzentowski, G Daubresse, J Mockel, J Behrends, J Servais, G Szpirer, C Kruys, V Gauguier, D Schurmans, S |
| author_facet | Marion, E Kaisaki, P Pouillon, V Gueydan, C Levy, J Bodson, A Krzentowski, G Daubresse, J Mockel, J Behrends, J Servais, G Szpirer, C Kruys, V Gauguier, D Schurmans, S |
| author_sort | Marion, E |
| collection | OXFORD |
| description | Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and is thus a good candidate gene. Here we report the presence of SHIP2 gene mutations associated with type 2 diabetes in rats and humans. The R1142C mutation specifically identified in Goto-Kakizaki (GK) and spontaneously hypertensive rat strains disrupts a potential class II ligand for Src homology (SH)-3 domain and slightly impairs insulin signaling in cell culture. In humans, a deletion identified in the SHIP2 3' untranslated region (UTR) of type 2 diabetic subjects includes a motif implicated in the control of protein synthesis. In cell culture, the deletion results in reporter messenger RNA and protein overexpression. Finally, genotyping of a cohort of type 2 diabetic and control subjects showed a significant association between the deletion and type 2 diabetes. Altogether, our results show that mutations in the SHIP2 gene contribute to the genetic susceptibility to type 2 diabetes in rats and humans. |
| first_indexed | 2024-03-07T01:28:27Z |
| format | Journal article |
| id | oxford-uuid:92c3a867-8afa-473e-9daf-ff356eff3896 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:28:27Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:92c3a867-8afa-473e-9daf-ff356eff38962022-03-26T23:27:53ZThe gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:92c3a867-8afa-473e-9daf-ff356eff3896EnglishSymplectic Elements at Oxford2002Marion, EKaisaki, PPouillon, VGueydan, CLevy, JBodson, AKrzentowski, GDaubresse, JMockel, JBehrends, JServais, GSzpirer, CKruys, VGauguier, DSchurmans, SGenetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and is thus a good candidate gene. Here we report the presence of SHIP2 gene mutations associated with type 2 diabetes in rats and humans. The R1142C mutation specifically identified in Goto-Kakizaki (GK) and spontaneously hypertensive rat strains disrupts a potential class II ligand for Src homology (SH)-3 domain and slightly impairs insulin signaling in cell culture. In humans, a deletion identified in the SHIP2 3' untranslated region (UTR) of type 2 diabetic subjects includes a motif implicated in the control of protein synthesis. In cell culture, the deletion results in reporter messenger RNA and protein overexpression. Finally, genotyping of a cohort of type 2 diabetic and control subjects showed a significant association between the deletion and type 2 diabetes. Altogether, our results show that mutations in the SHIP2 gene contribute to the genetic susceptibility to type 2 diabetes in rats and humans. |
| spellingShingle | Marion, E Kaisaki, P Pouillon, V Gueydan, C Levy, J Bodson, A Krzentowski, G Daubresse, J Mockel, J Behrends, J Servais, G Szpirer, C Kruys, V Gauguier, D Schurmans, S The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. |
| title | The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. |
| title_full | The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. |
| title_fullStr | The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. |
| title_full_unstemmed | The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. |
| title_short | The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. |
| title_sort | gene inppl1 encoding the lipid phosphatase ship2 is a candidate for type 2 diabetes in rat and man |
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