Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.

Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.

Glucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In diabetes, glucagon secretion is not suppressed at high glucose, exacerbating the consequences of insufficient insulin secretion, and is inadequate at low glucose, potentially leading to fatal hypoglycemia. The...

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Bibliographic Details
Main Authors: Zhang, Q, Ramracheya, R, Lahmann, C, Tarasov, A, Bengtsson, M, Braha, O, Braun, M, Brereton, M, Collins, S, Galvanovskis, J, Gonzalez, A, Groschner, L, Rorsman, N, Salehi, A, Travers, M, Walker, J, Gloyn, A, Gribble, F, Johnson, P, Reimann, F, Ashcroft, F, Rorsman, P
Format: Journal article
Language:English
Published: 2013

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