The Transcellular Propagation and Intracellular Trafficking of α-Synuclein

Parkinson’s disease is the second most common neurodegenerative disorder, with only partial symptomatic therapy and no mechanism-based therapies. The accumulation and aggregation of α-synuclein is causatively linked to the sporadic form of the disease, which accounts for 95% of cases. The pathology...

Полное описание

Библиографические подробности
Главные авторы: Tofaris, GK, Goedert, M, Spillantini, MG
Формат: Journal article
Опубликовано: Cold Spring Harbor Laboratory Press 2016