Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts

Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts

The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS-coronavirus (TMPRSS2) in cell culture and may play an important role in viral spread and pathogenesis in the infected host. However, it is at present largely unclear to what extent these proteases are...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Bertram, S, Heurich, A, Lavender, H, Gierer, S, Danisch, S, Perin, P, Lucas, J, Nelson, P, Pöhlmann, S, Soilleux, E
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	Public Library of Science 2012

Gelijkaardige items

Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
door: Stephanie Bertram, et al.
Gepubliceerd in: (2012-01-01)

Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT.
door: Katiuchia Uzzun Sales, et al.
Gepubliceerd in: (2011-01-01)

Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.
door: Lennart Michel Reinke, et al.
Gepubliceerd in: (2017-01-01)

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease
door: Bertram, S, et al.
Gepubliceerd in: (2011)

TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses
door: Gilmara Barros de Lima, et al.
Gepubliceerd in: (2025-01-01)

Genetic Analysis of the Coronavirus SARS-CoV-2 Host Protease TMPRSS2 in Different Populations
door: Roberta Russo, et al.
Gepubliceerd in: (2020-08-01)

Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.
door: Pawel Zmora, et al.
Gepubliceerd in: (2017-01-01)

Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease
door: Annelies Stevaert, et al.
Gepubliceerd in: (2022-08-01)

H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice
door: Ruth Lydia Olga Lambertz, et al.
Gepubliceerd in: (2020-04-01)

Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells
door: Marie Schwerdtner, et al.
Gepubliceerd in: (2024-11-01)

The Transmembrane Protease Serine 2 (TMPRSS2) Non-Protease Domains Regulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike-Mediated Virus Entry
door: Romano Strobelt, et al.
Gepubliceerd in: (2023-10-01)

Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19
door: Rosalinda Posadas-Sánchez, et al.
Gepubliceerd in: (2022-09-01)

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
door: Lukas Wettstein, et al.
Gepubliceerd in: (2021-03-01)

TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.
door: Pawel Zmora, et al.
Gepubliceerd in: (2015-01-01)

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2
door: Nurit P Azouz, et al.
Gepubliceerd in: (2021-04-01)

Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2)
door: Noor Rahman, et al.
Gepubliceerd in: (2020-05-01)

Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19
door: Sepehr Shafiee, et al.
Gepubliceerd in: (2021-08-01)

COVID-19 pandemic; transmembrane protease serine 2 (TMPRSS2) inhibitors as potential drugs.
door: Jerzy Jankun
Gepubliceerd in: (2020-04-01)

Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers
door: Mehmet Arda Temena, et al.
Gepubliceerd in: (2022-08-01)

TMPRSS4, a type II transmembrane serine protease, as a potential therapeutic target in cancer
door: Semi Kim
Gepubliceerd in: (2023-04-01)

Blocking serine protease (TMPRSS2) by Bromhexine; looking at potential treatment to prevent COVID-19 infection
door: Ramin Tolouian, et al.
Gepubliceerd in: (2020-07-01)

Spontaneous binding of potential COVID-19 drugs (Camostat and Nafamostat) to human serine protease TMPRSS2
door: Haixia Zhu, et al.
Gepubliceerd in: (2021-01-01)

Proteases in gastrointestinal tissues /
door: Lendeckel, Uwe, et al.
Gepubliceerd in: (2006)

NanoLuciferase technology-based detection of TMPRSS2 as attempt to develop anti-coronavirus agents
door: Yanwen Chen, et al.
Gepubliceerd in: (2024-09-01)

A Tale of Two Proteases: M<sup>Pro</sup> and TMPRSS2 as Targets for COVID-19 Therapies
door: Barbara Farkaš, et al.
Gepubliceerd in: (2023-06-01)

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients
door: Andrea Sacconi, et al.
Gepubliceerd in: (2020-09-01)

SARS-CoV-2 Targets by the pscRNA Profiling of ACE2, TMPRSS2 and Furin Proteases
door: Lulin Zhou, et al.
Gepubliceerd in: (2020-11-01)

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
door: Barrett L. Updegraff, et al.
Gepubliceerd in: (2018-11-01)

<em>Scutellaria barbata</em> D. Don Inhibits the Main Proteases (M<sup>pro</sup> and TMPRSS2) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
door: Sheng-Teng Huang, et al.
Gepubliceerd in: (2021-05-01)

Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections
door: Ben M. Flude, et al.
Gepubliceerd in: (2021-02-01)

« Is that wool hat my hat ? »
door: Hélène Aji
Gepubliceerd in: (2006-06-01)

Functional Disorders of the Gastrointestinal Tract During the Pandemic of a New Coronavirus Infection
door: A. A. Sheptulin, et al.
Gepubliceerd in: (2022-09-01)

Impaired tryptophan metabolism in the gastrointestinal tract of patients with critical coronavirus disease 2019
door: Yoshihiro Yokoyama, et al.
Gepubliceerd in: (2022-08-01)

Correction: Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice.
Gepubliceerd in: (2014-09-01)

Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.
door: Anna Keppner, et al.
Gepubliceerd in: (2015-01-01)

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein
door: Mai Kishimoto, et al.
Gepubliceerd in: (2021-02-01)

Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury.
door: Ana Valero-Jiménez, et al.
Gepubliceerd in: (2018-01-01)

Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L.
door: Kartikay Prasad, et al.
Gepubliceerd in: (2021-01-01)

Generation of a Porcine Cell Line Stably Expressing Pig TMPRSS2 for Efficient Isolation of Swine Influenza Virus
door: Yuri L Tanaka, et al.
Gepubliceerd in: (2023-12-01)

Gáspár Gabriella: Hat falu hat sorsa
door: Kugler József
Gepubliceerd in: (1987-12-01)