Engineering cytochrome P450BM3 into a drug metabolising enzyme
<p>Directed evolution studies by Whitehouse et al. identified several variants of P450BM3 (CYP102A1) with enhanced substrate oxidation rates across a range of substrates. This thesis describes the use of these ‘generic accelerator’ variants, in combination with selectivity altering mutations t...
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| Format: | Thesis |
| Language: | English |
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2012
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