How G4 ligands enhance the innate immune response in BRCA1/2- deficient cells and tumours

<p>G-quadruplex binding ligands, like pyridostatin, are known to cause DNA damage and eventually trigger apoptosis (Rodriguez et al., 2012; Zimmer et al., 2016). The stabilisation of G-quadruplexes causes replication fork stalling resulting in DNA damage accumulation and subsequent activation...