Telomere structure and maintenance gene variants and risk of five cancer types

Telomere structure and maintenance gene variants and risk of five cancer types

Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-end fusions. Telomeres are maintained by telomerase, a reverse transcriptase encoded by TERT, and an RNA template encoded by TERC. Loci in the TERT and adjoining CLPTM1L region are associated with risk...

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Main Authors: Karami, S, Han, Y, Pande, M, Cheng, I, Rudd, J, Pierce, BL, Nutter, EL, Schumacher, FR, Kote-Jarai, Z, Lindstrom, S, Witte, JS, Fang, S, Han, J, Kraft, P, Hunter, DJ, Song, F, Hung, RJ, McKay, J, Gruber, SB, Chanock, SJ, Risch, A, Shen, H, Haiman, CA, Boardman, L, Ulrich, CM, Casey, G, Peters, U, Olama, A, Berchuck, A, Berndt, SI, Bezieau, S, Brennan, P, Brenner, H, Brinton, L, Caporaso, N, Chan, AT, Chang-Claude, J, Christiani, DC, Cunningham, JM, Easton, D, Eeles, RA, Eisen, T, Gala, M, Gallinger, SJ, Gayther, SA, Goode, EL, Grönberg, H, Henderson, BE, Houlston, R, Joshi, AD, Küry, S, Landi, MT, Le Marchand, L, Muir, K, Newcomb, PA, Permuth-Wey, J, Pharoah, P, Phelan, C, Potter, JD, Ramus, SJ, Risch, H, Schildkraut, J, Slattery, ML, Song, H, Wentzensen, N, White, E, Wiklund, F, Zanke, BW, Sellers, TA, Zheng, W, Chatterjee, N, Amos, CI, Doherty, JA, GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL
Format: Journal article
Language:English
Published: Wiley 2016

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