Telomere structure and maintenance gene variants and risk of five cancer types

Telomere structure and maintenance gene variants and risk of five cancer types

Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-end fusions. Telomeres are maintained by telomerase, a reverse transcriptase encoded by TERT, and an RNA template encoded by TERC. Loci in the TERT and adjoining CLPTM1L region are associated with risk...

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Detalhes bibliográficos
Principais autores: Karami, S, Han, Y, Pande, M, Cheng, I, Rudd, J, Pierce, BL, Nutter, EL, Schumacher, FR, Kote-Jarai, Z, Lindstrom, S, Witte, JS, Fang, S, Han, J, Kraft, P, Hunter, DJ, Song, F, Hung, RJ, McKay, J, Gruber, SB, Chanock, SJ, Risch, A, Shen, H, Haiman, CA, Boardman, L, Ulrich, CM, Casey, G, Peters, U, Olama, A, Berchuck, A, Berndt, SI, Bezieau, S, Brennan, P, Brenner, H, Brinton, L, Caporaso, N, Chan, AT, Chang-Claude, J, Christiani, DC, Cunningham, JM, Easton, D, Eeles, RA, Eisen, T, Gala, M, Gallinger, SJ, Gayther, SA, Goode, EL, Grönberg, H, Henderson, BE, Houlston, R, Joshi, AD, Küry, S, Landi, MT, Le Marchand, L, Muir, K, Newcomb, PA, Permuth-Wey, J, Pharoah, P, Phelan, C, Potter, JD, Ramus, SJ, Risch, H, Schildkraut, J, Slattery, ML, Song, H, Wentzensen, N, White, E, Wiklund, F, Zanke, BW, Sellers, TA, Zheng, W, Chatterjee, N, Amos, CI, Doherty, JA, GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL
Formato: Journal article
Idioma:English
Publicado em: Wiley 2016

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