Constitutively active ALK2 receptor mutants require type II receptor cooperation.
Constitutively activating mutations in receptor kinases recruit downstream effector pathways independently of upstream signaling, with consequences ranging from developmental syndromes to cancer. Classic fibrodysplasia ossificans progressiva (FOP) is a congenital syndrome resulting from highly cons...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | eng |
| Published: |
2013
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