Genotype-dependent effects of COMT inhibition on cognitive function in a highly-specific, novel mouse model of altered COMT activity
Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex (PFC). The human gene contains a polymorphism (Val158Met) that alters enzyme activity and influences PFC function. It has also been linked with cognition and anxiety, but findings are mixed. We therefore develope...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
Nature Publishing Group
2016
|