Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.
Spinal muscular atrophy is a severe motor neuron disease caused by inactivating mutations in the SMN1 gene leading to reduced levels of full-length functional SMN protein. SMN is a critical mediator of spliceosomal protein assembly, and complete loss or drastic reduction in protein leads to loss of...
Main Authors: | , , , , , , , , , |
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Format: | Journal article |
Sprog: | English |
Udgivet: |
2009
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