Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.

Spinal muscular atrophy is a severe motor neuron disease caused by inactivating mutations in the SMN1 gene leading to reduced levels of full-length functional SMN protein. SMN is a critical mediator of spliceosomal protein assembly, and complete loss or drastic reduction in protein leads to loss of...

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Bibliografiske detaljer
Main Authors: Bäumer, D, Lee, S, Nicholson, G, Davies, J, Parkinson, N, Murray, L, Gillingwater, T, Ansorge, O, Davies, K, Talbot, K
Format: Journal article
Sprog:English
Udgivet: 2009