An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of...

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Autori principali: Liu, J, Carnero-Montoro, E, Van Dongen, J, Lent, S, Nedeljkovic, I, Ligthart, S, Tsai, P, Martin, T, Mandaviya, P, Jansen, R, Peters, M, Duijts, L, Jaddoe, V, Tiemeier, H, Felix, J, Willemsen, G, De Geus, E, Chu, A, Levy, D, Hwang, S, Bressler, J, Gondalia, R, Salfati, E, Herder, C, Hidalgo, B, Tanaka, T, Moore, A, Lemaitre, R, Jhun, M, Smith, J, Sotoodehnia, N, Bandinelli, S, Ferrucci, L, Arnett, D, Grallert, H, Assimes, T, Hou, L, Baccarelli, A, Whitsel, E, Van Dijk, K, Amin, N, Uitterlinden, A, Sijbrands, E, Franco, O, Dehghan, A, Spector, T, Dupuis, J, Hivert, M, Rotter, J, Meigs, J, Pankow, J, Van Meurs, J, Isaacs, A, Boomsma, D, Bell, J, Demirkan, A, Van Duijn, C
Natura: Journal article
Lingua:English
Pubblicazione: Nature Research 2019

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