A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.

K13 gene mutations are a primary marker of artemisinin resistance in Plasmodium falciparum malaria that threatens the long-term clinical utility of artemisinin-based combination therapies, the cornerstone of modern day malaria treatment. Here we describe a multinational drug discovery programme that...

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Bibliographic Details
Main Authors: O'Neill, P, Amewu, R, Charman, S, Sabbani, S, Gnädig, N, Straimer, J, Fidock, D, Shore, E, Roberts, N, Wong, M, Hong, W, Pidathala, C, Riley, C, Murphy, B, Aljayyoussi, G, Gamo, F, Sanz, L, Rodrigues, J, Cortes, C, Herreros, E, Angulo-Barturén, I, Jiménez-Díaz, M, Bazaga, S, Martínez-Martínez, M, Campo, B, Sharma, R, Ryan, E, Shackleford, D, Campbell, S, Smith, D, Wirjanata, G, Noviyanti, R, Price, R, Marfurt, J, Palmer, M, Copple, I, Mercer, A, Ruecker, A, Delves, M, Sinden, R, Siegl, P, Davies, J, Rochford, R, Kocken, C, Zeeman, A, Nixon, G, Biagini, G, Ward, S
Format: Journal article
Language:English
Published: Nature Publishing Group 2017

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