The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel.

The extracellular matrix (ECM) can induce chemotherapy resistance via AKT-mediated inhibition of apoptosis. Here, we show that loss of the ECM protein TGFBI (transforming growth factor beta induced) is sufficient to induce specific resistance to paclitaxel and mitotic spindle abnormalities in ovaria...

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Bibliographic Details
Main Authors:	Ahmed, A, Mills, A, Ibrahim, A, Temple, J, Blenkiron, C, Vias, M, Massie, C, Iyer, N, McGeoch, A, Crawford, R, Nicke, B, Downward, J, Swanton, C, Bell, S, Earl, H, Laskey, R, Caldas, C, Brenton, J
Format:	Journal article
Language:	English
Published:	2007

The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel.

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