Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.

The emergence of tumor resistance to conventional microtubule-targeting drugs restricts their clinical use. Using a cell-based assay that recognizes microtubule polymerization status to screen for chemicals that interact with regulators of microtubule dynamics, we identified Pyr1, a cell permeable i...

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Bibliographic Details
Main Authors:	Prudent, R, Vassal-Stermann, E, Nguyen, C, Pillet, C, Martinez, A, Prunier, C, Barette, C, Soleilhac, E, Filhol, O, Beghin, A, Valdameri, G, Honoré, S, Aci-Sèche, S, Grierson, D, Antonipillai, J, Li, R, Di Pietro, A, Dumontet, C, Braguer, D, Florent, J, Knapp, S, Bernard, O, Lafanechère, L
Format:	Journal article
Language:	English
Published:	2012

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.

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