Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins.

Cotranslational protein folding can facilitate rapid formation of functional structures. However, it might also cause premature assembly of protein complexes, if two interacting nascent chains are in close proximity. By analyzing known protein structures, we show that homomeric protein contacts are...

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Bibliographic Details
Main Authors: Natan, E, Endoh, T, Haim-Vilmovsky, L, Flock, T, Chalancon, G, Hopper, JTS, Kintses, B, Horvath, P, Daruka, L, Fekete, G, Pál, C, Papp, B, Oszi, E, Magyar, Z, Marsh, JA, Elcock, AH, Babu, MM, Robinson, CV, Sugimoto, N, Teichmann, SA
Format: Journal article
Language:English
Published: Nature Publishing Group 2018