Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates
T cells use their T cell receptors (TCRs) to discriminate between lower‐affinity self and higher‐affinity foreign peptide major‐histocompatibility‐complexes (pMHCs) based on the TCR/pMHC off‐rate. It is now appreciated that T cells generate mechanical forces during this process but how force impa...
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| Médium: | Journal article |
| Jazyk: | English |
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EMBO Press
2022
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