Studies towards squalene synthase inhibitors: total synthesis of 6,7-dideoxysqualestatin h5 via an alkene-protection strategy
<p>The zaragozic acids/squalestatins are a family of bicyclic tricarboxylic acids, isolated from a series of different fungi. Members of this class of highly oxygenated natural products show potent inhibitory activity against squalene synthase at the last stage of cholesterol biosynthesis,...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Published: |
2019
|